BASIC PRINCIPLES OF ANIMAL CARE


mice | rabbits | rats | references

Weight
The average mouse weighs less than an ounce (30 grams) and can live up to three years.

[ top of page ]

Handling
If you are not accustomed to handling mice, it is advisable to wear a snug fitting glove when handling them. To move a mouse, pick it up by its tail with your thumb and first finger grasping it close to the body (if taken by the tip, the whole skin covering may come off). Make sure to leave the mouse in a head down position for only a few seconds, otherwise the mouse may turn, crawl up its own tail, and bite you. To restrain a mouse, grasp by the base of the tail, place it on a surface that it can grip with its froe feet so that you can stretch the body out, then grasp a fold of the loose skin over the neck and shoulders just tight enough to keep the mouse from turning it's head and biting.

 [ top of page ]


Housing
Mice are normally kept in cages measuring six by twelve by six inches high (15x30x15cm) with a solid bottom. The floor is usually covered with one to two inches of woodchips, ground corncobs, sawdust, hay, or any other material available (do not use newsprint, the ink may make the mice sick). The bedding should be changed at least once weekly.

 
[ top of page ]

Feeding: 
Mice are nocturnal animals and tend to feed more at nights, however, it is advisable for laboratory animals to have food and water ad libitum (except where experimental procedures dictate otherwise). When using pellets, make sure they small fresh and clean. If they smell musty and moldy, the pellets are old and shouldn't be used. Water bottles should be washed and replaced at least once weekly. Diets can be supplemented with snacks such as cracked corn and/or oil sunflower seeds.

 
[ top of page ]

Breeding: 
Female mice are old enough to breed at two months and can have up to seventeen litters a year with an average of five to ten babies per litter. Her reproductive cycle (estrous cycle) makes it possible for her to accept a male every fourth day and so mating occurs often if the male and female are continuously kept in the same cage. More than one female may be kept in one cage with a male (as long as each female has her own nesting box), but it is not recommended to keep two or more males in one cage. When multiple males are housed together they will fight to establish dominance. The Gestation period in mice lasts nineteen to twenty one days. Immediately following birth, babies are tiny, helpless, and hairless weighing approximately one gram. Their eyes are sealed for the first two weeks of life. After they have been weaned, male babies should be placed in separate cages, but female babies can remain together.

 
[ top of page ]

Diseases:

Bite wounds: 
Bite wounds will occur between fighting males or overcrowded females. Treat them with a small amount of antibiotic ointment but be careful not to use too much or the mice will eat it when they groom themselves.

Antibiotic Toxicity: 
Mice are sensitive to streptomycin which can kill them if injected.

Respiratory Infections and Pneumonia: 
Mice suffering from respiratory infections and pneumonia sit in a corner with fur ruffled up. Discharge from their nose, and chattering noise as they breathe may also be observed. -Antibiotics such as chloramphenicol or tetracyclene can be given orally (5mg). twice daily for 4 or 5 days. A 250 mg. capsule of antibiotic can be dissolved in a cupful of water (240cc) and placed in their water bottle. A half teaspoon of sugar can be added to sweeten the water. They should receive 4 to 5 mg of antibiotic daily with this procedure and should be kept on the medication for 5 days.

Diarrhea: 
Diarrhea may result from improper diet, spoiled food or internal parasites. Replace pellets if they smell musty or smell/look moldy. If there is no improvement in 24 to 48 hours, collect a sample of stool in a plastic vial and have the Vet examine it for internal parasites. If there are parasites the Vet can prescribe the appropriate medication.

Tumor: 
A tumor is any unusual lump or swelling growing on or in the mouse. Mice are susceptible to tumors and they are common in middle aged and older mice. Some can be removed surgically. Many are malignant and have probably spread extensively before being observed. These mice need to be euthanized to prevent suffering.

Fur chewing: 
Fur chewing is an indication that the mice are too crowded. Over crowded mice will chew the fur off each others faces. If this occurs they should be placed in separate cages or in larger cages.

Mites, fleas, lice: 
Mites, fleas, and lice are not commonly seen in mice. If found, their fur should be treated by applying a rotenone-based flea powder weekly. A Shell pest strip containing Vapona may also be placed on top of the cage one night weekly. The strip should not be left on the cage continuously or placed where the mice can chew on it or lick it.

 [ top of page ]


 

Copyright © 2012 Minnesota State University Moorhead
Minnesota State University Moorhead | 1104 7th Ave South | Moorhead, MN 56563 USA | 1.800.593.7246
a member of the minnesota state colleges and universities system (mnscu)
mission | an equal opportunity educator and employer | accessibility questions? | contact us | updated 2/28/12